Bicarbonate Ion → 6-{[(3-Fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[CH:11]([CH2:14][NH:15][c:16]3[cH:17][c:18]([F:28])[c:19]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[cH:20][cH:21]3)[CH:12]2[CH2:13]1.[CH:29]([N:30]([CH2:31][CH3:32])[CH:33]([CH3:34])[CH3:35])([CH3:36])[CH3:37].[Na+:50].[O-:46][C:47]([OH:48])=[O:49].[s:38]1[c:39]([C:43](=[O:44])[Cl:45])[cH:40][cH:41][cH:42]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[CH:11]([CH2:14][N:15]([c:16]3[cH:17][c:18]([F:28])[c:19]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[cH:20][cH:21]3)[C:43]([c:39]3[s:38][cH:42][cH:41][cH:40]3)=[O:44])[CH:12]2[CH2:13]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-560775f44eca4c96845fa0f4f7e5a5fb
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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