Dichloromethane → 4-(Cyclopropylmethoxy)piperidine

HRID 955208Notes

Reaction equation

HRID 955208 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][CH:16]2[CH2:17][CH2:18]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:26][CH2:27][Cl:28].[F:19][C:20]([F:21])([F:22])[C:23]([OH:24])=[O:25]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][CH:16]2[CH2:17][CH2:18]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 689110854-Cyclopropylmethoxypiperidine-1-carboxylic acid t-butyl ester

Product 1

HCID 171780104-(Cyclopropylmethoxy)piperidine

Sources & evidence

ORD record
ord-28f1b4d641d546eeb9ce4bceeda9e026
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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