Dichloromethane → 6-(3,4,5-Trifluorophenyl)-1,2,3,6,9,9a-hexahydroquinolizin-4-one

HRID 95535Notes

Reaction equation

[CH2:34]([Cl:35])[Cl:36].[CH3:1][S:2](=[O:3])(=[O:4])[Cl:5].[CH3:6][CH2:7][N:8]([CH2:9][CH3:10])[CH2:11][CH3:12].[OH:13][CH:14]1[CH2:15][CH:16]([c:25]2[cH:26][c:27]([F:33])[c:28]([F:32])[c:29]([F:31])[cH:30]2)[N:17]2[C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH:22]2[CH2:23]1>>[CH:14]1=[CH:15][CH:16]([c:25]2[cH:26][c:27]([F:33])[c:28]([F:32])[c:29]([F:31])[cH:30]2)[N:17]2[C:18](=[O:24])[CH2:19][CH2:20][CH2:21][CH:22]2[CH2:23]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 31297Methanesulfonyl chloride

HCID 687177428-Hydroxy-6-(3,4,5-trifluorophenyl)-1,2,3,6,7,8,9,9a-octahydroquinolizin-4-one

Product 1

HCID 690751206-(3,4,5-Trifluorophenyl)-1,2,3,6,9,9a-hexahydroquinolizin-4-one

Sources & evidence

ORD record: ord-997d469fb9544a09866be5ff31c94b74
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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