Dimethylamine → tert-Butyl 4-[1-dimethylamino-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate

HRID 955357Notes

Reaction equation

HRID 955357 reaction equation
[C:10](=[O:11])([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[N:17]1[CH2:18][CH2:19][CH:20]([CH:23]=[O:24])[CH2:21][CH2:22]1.[C:1](#[CH:2])[c:3]1[n:4][c:5]([CH3:9])[cH:6][cH:7][cH:8]1.[CH3:25][NH:26][CH3:27].[Cu:29][I:30].[OH2:28]>>[C:1](#[C:2][CH:23]([CH:20]1[CH2:19][CH2:18][N:17]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:22][CH2:21]1)[N:26]([CH3:25])[CH3:27])[c:3]1[n:4][c:5]([CH3:9])[cH:6][cH:7][cH:8]1

Participants

6

Reactant 5

HCID 674DimethylamineHCID 962WaterHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 1514430tert-Butyl 4-formylpiperidine-1-carboxylateHCID 134006352-Ethynyl-6-methylpyridine

Product 1

HCID 68724984tert-Butyl 4-[1-dimethylamino-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-25bea096b2704c0fa97bb30533617ed2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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