Phenol → 8-(4-Phenoxy-bicyclo[2.2.2]oct-1-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione

HRID 955478Notes

Reaction equation

HRID 955478 reaction equation
[CH2:60]1[O:61][CH2:62][CH2:63][O:64][CH2:65]1.[Cl:57][CH2:58][Cl:59].[F:27][C:28]([S:29]([O:30][S:31]([C:32]([F:33])([F:34])[F:35])(=[O:36])=[O:37])(=[O:38])=[O:39])([F:40])[F:41].[O-:42][S:43]([C:44]([F:45])([F:46])[F:47])(=[O:48])=[O:49].[OH:1][C:2]12[CH2:3][CH2:4][C:5]([c:10]3[n:11][c:12]4[n:13]([CH2:24][CH2:25][CH3:26])[c:14](=[O:23])[n:15]([CH2:20][CH2:21][CH3:22])[c:16](=[O:19])[c:17]4[nH:18]3)([CH2:6][CH2:7]1)[CH2:8][CH2:9]2.[OH:50][c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1.[cH:66]1[cH:67][cH:68][n:69][cH:70][cH:71]1>>[O:1]([C:2]12[CH2:3][CH2:4][C:5]([c:10]3[n:11][c:12]4[n:13]([CH2:24][CH2:25][CH3:26])[c:14](=[O:23])[n:15]([CH2:20][CH2:21][CH3:22])[c:16](=[O:19])[c:17]4[nH:18]3)([CH2:6][CH2:7]1)[CH2:8][CH2:9]2)[c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1

Participants

8

Reactant 7

HCID 996PhenolHCID 1049PyridineHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 67749Trifluoromethanesulfonic anhydrideHCID 2758875TrifluoromethanesulfonateHCID 99507768-(4-hydroxybicyclo[2.2.2]octan-1-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione

Product 1

HCID 187676228-(4-Phenoxy-bicyclo[2.2.2]oct-1-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione

Sources & evidence

ORD record
ord-3d7699c2c91b443082834e2111327308
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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