Acetate → 4-(4-Amino-3-cyclohex-1-enyl-phenyl)-piperidine-2,6-dione
Reaction equation
[C:17]1([B:23]([OH:24])[OH:25])=[CH:18][CH2:19][CH2:20][CH2:21][CH2:22]1.[CH3:59][c:60]1[cH:61][cH:62][cH:63][cH:64][cH:65]1.[CH3:66][CH2:67][O:68][C:69]([CH3:70])=[O:71].[CH:34]1([P:35]([CH:36]2[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][c:47]2-[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[CH2:54][CH2:55][CH2:56][CH2:57][CH2:58]1.[K+:31].[K+:32].[K+:33].[NH2:1][c:2]1[c:3]([Br:16])[cH:4][c:5]([CH:8]2[CH2:9][C:10](=[O:15])[NH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1.[O-:73][C:74]([CH3:75])=[O:76].[O-:77][C:78]([CH3:79])=[O:80].[O:81]1[CH2:82][CH2:83][O:84][CH2:85][CH2:86]1.[P:26]([O-:27])([O-:28])([O-:29])=[O:30].[Pd+2:72]>>[NH2:1][c:2]1[c:3]([C:17]2=[CH:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:4][c:5]([CH:8]2[CH2:9][C:10](=[O:15])[NH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1Participants
11
Reactant 10
HCID 175Acetate2×
HCID 813Potassium Cation3×
HCID 1061Phosphate
HCID 1140Toluene
HCID 8857Ethyl Acetate
HCID 312751,4-Dioxane
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 27342162-(Dicyclohexylphosphino)biphenyl
HCID 38629021-Cyclohexenylboronic acid
HCID 597712744-(4-Amino-3-bromo-phenyl)-piperidine-2,6-dioneProduct 1
Sources & evidence
- ORD record
- ord-1b01e5fc3b0444ba9bcb401774f02f3a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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