Tetrahydrofuran → 1-Benzyloxycarbonyl-4-hydroxy-4-(4-benzyloxyphenyl)piperidine

HRID 955635Notes

Reaction equation

HRID 955635 reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH2:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([Br:20])[cH:18][cH:19]1.[O:21]=[C:22]1[CH2:23][CH2:24][N:25]([C:28](=[O:29])[O:30][CH2:31][c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[CH2:26][CH2:27]1>>[CH2:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[O:13][c:14]1[cH:15][cH:16][c:17]([C:22]2([OH:21])[CH2:23][CH2:24][N:25]([C:28](=[O:29])[O:30][CH2:31][c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[CH2:26][CH2:27]2)[cH:18][cH:19]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 1388351-Bromo-4-phenylmethoxybenzeneHCID 643496Benzyl 4-oxopiperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 218398431-Benzyloxycarbonyl-4-hydroxy-4-(4-benzyloxyphenyl)piperidine

Sources & evidence

ORD record
ord-055c1d0527524a6e87abdd433bb908d2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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