Dimethyl Sulfoxide → 2-[2-[1-(5-Chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]acetaldehyde
Reaction equation
[CH3:7][S:8]([CH3:9])=[O:10].[Cl:11][c:12]1[cH:13][n:14][c:15]([N:18]2[CH2:19][CH2:20][CH:21]([CH:24]3[CH:25]([CH2:27][CH2:28][OH:29])[CH2:26]3)[CH2:22][CH2:23]2)[n:16][cH:17]1.[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:30][CH2:31][Cl:32].[OH2:33]>>[Cl:11][c:12]1[cH:13][n:14][c:15]([N:18]2[CH2:19][CH2:20][CH:21]([CH:24]3[CH:25]([CH2:27][CH:28]=[O:29])[CH2:26]3)[CH2:22][CH2:23]2)[n:16][cH:17]1Participants
6
Sources & evidence
- ORD record
- ord-438220070c384476b0c34f8c42259965
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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