Tetrahydrofuran → Tert-butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

HRID 955708Notes

Reaction equation

HRID 955708 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][C:14]([F:16])([F:17])[CH2:15]1.[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:10][OH:11])[CH2:13][C:14]([F:16])([F:17])[CH2:15]1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 235125141-((Tert-butoxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid

Product 1

HCID 22001352Tert-butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-f4ee8a04fad94df1b4df5aa23050a50f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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