Hydrogen Bromide → 3-Cyanomethyl-5-fluoro-2-methyl-7-(2-hydroxyphenacyl)pyrrolo[2,3-b]pyridine

HRID 955726Notes

Reaction equation

HRID 955726 reaction equation
[B:27]([Br:28])([Br:29])[Br:30].[BrH:1].[C:2](#[N:3])[CH2:4][c:5]1[c:6]([CH3:26])[n:7][c:8]2[n:9]([CH2:15][C:16](=[O:17])[c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[cH:10][c:11]([F:14])[cH:12][c:13]1-2.[CH2:31]([Cl:32])[Cl:33]>>[C:2](#[N:3])[CH2:4][c:5]1[c:6]([CH3:26])[n:7][c:8]2[n:9]([CH2:15][C:16](=[O:17])[c:18]3[c:19]([OH:24])[cH:20][cH:21][cH:22][cH:23]3)[cH:10][c:11]([F:14])[cH:12][c:13]1-2

Participants

5

Reactant 4

HCID 260Hydrogen BromideHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 199168172-[5-Fluoro-7-[2-(2-methoxyphenyl)-2-oxoethyl]-2-methylpyrrolo[2,3-b]pyridin-3-yl]acetonitrile

Product 1

HCID 199168033-Cyanomethyl-5-fluoro-2-methyl-7-(2-hydroxyphenacyl)pyrrolo[2,3-b]pyridine

Sources & evidence

ORD record
ord-99a69a73291e46a2b9477142eca466f9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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