2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 2-Chloro-4-[1-(2,2-difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine
Reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][Si:10]([CH3:11])([CH3:12])[CH3:13])[cH:7]1.[F:14][CH:15]([CH2:16][n:17]1[c:18]([CH3:23])[n:19][c:20]([I:22])[cH:21]1)[F:24]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:20]2[n:19][c:18]([CH3:23])[n:17]([CH2:16][CH:15]([F:14])[F:24])[cH:21]2)[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-e6ed28f47ed24e29aa379acc92be5873
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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