Piperidin-4-ol → tert-butyl N-[3-(4-fluorophenyl)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl]carbamate

HRID 956112Notes

Reaction equation

HRID 956112 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[NH:8][CH:9]([CH2:10][c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[C:18](=[O:19])[OH:20].[OH:21][CH:22]1[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[NH:8][CH:9]([CH2:10][c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[C:18](=[O:20])[N:25]1[CH2:24][CH2:23][CH:22]([OH:21])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 27567942-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid

Product 1

HCID 21710729tert-butyl N-[3-(4-fluorophenyl)-1-(4-hydroxypiperidin-1-yl)-1-oxopropan-2-yl]carbamate

Sources & evidence

ORD record
ord-9733e98f10474b3c819cf7ae529f18e3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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