Sodium ion → 2-Chloro-4-[5-chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-benzonitrile

HRID 956146Notes

Reaction equation

HRID 956146 reaction equation
[Br:19][c:20]1[cH:21][n:22][cH:23][c:24]([Cl:29])[c:25]1[CH:26]([CH3:27])[OH:28].[C:33](=[O:34])([O-:35])[O-:36].[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([B:10]2[O:11][C:12]([CH3:13])([CH3:14])[C:15]([CH3:16])([CH3:17])[O:18]2)[cH:9]1.[Cl:30][CH2:31][Cl:32].[Na+:37].[Na+:38].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8](-[c:20]2[cH:21][n:22][cH:23][c:24]([Cl:29])[c:25]2[CH:26]([CH3:27])[OH:28])[cH:9]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 579261132-Chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 671550211-(3-Bromo-5-chloro-pyridin-4-yl)-ethanol

Product 1

HCID 711049252-Chloro-4-[5-chloro-4-(1-hydroxy-ethyl)-pyridin-3-yl]-benzonitrile

Sources & evidence

ORD record
ord-e00ed7b3181246f2b5d1d1b42a5820ed
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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