Dichloromethane → 5-Bromo-1-methyl-3-(4-(piperidin-4-yl)phenylamino)pyrazin-2(1H)-one

HRID 956345Notes

Reaction equation

[Br:1][c:2]1[cH:3][n:4]([CH3:29])[c:5](=[O:28])[c:6]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1.[CH2:37]([Cl:38])[Cl:39].[OH:30][C:31]([C:32]([F:33])([F:34])[F:35])=[O:36]>>[Br:1][c:2]1[cH:3][n:4]([CH3:29])[c:5](=[O:28])[c:6]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58043998tert-Butyl 4-(4-(6-Bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-ylamino)phenyl)piperidine-1-carboxylate

Product 1

HCID 580437455-Bromo-1-methyl-3-(4-(piperidin-4-yl)phenylamino)pyrazin-2(1H)-one

Sources & evidence

ORD record: ord-5bb25b306414446992a5c095926b38ff
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…