Trifluoroacetic acid → 4-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

HRID 956582Notes

Reaction equation

HRID 956582 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:9](=[O:12])[cH:10][n:11]2)[n:29]1.[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36].[NH2:37][CH:38]1[CH2:39][CH2:40][N:41]([CH2:42][CH2:43][n:44]2[c:45]3[c:46]([cH:47][c:48]([C:49]#[N:50])[cH:51][cH:52]3)[n:53][cH:54][c:55]2=[O:56])[CH2:57][CH2:58]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:9](=[O:12])[cH:10][n:11]2)[n:29]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 57815384tert-Butyl {1-[2-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl]piperidin-4-yl}carbamateHCID 667741351-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoxaline-6-carbonitrile

Product 1

HCID 578153944-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

Sources & evidence

ORD record
ord-197132d9ad02436a8215012ca2312c7e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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