Piperidin-4-ol → 1-(4-Hydroxypiperidin-1-yl)-6-methoxy-4-phenylisoquinoline-3-carbonitrile
Reaction equation
[CH2:1]([NH:2][c:5]1[n:6][c:7]([C:23]#[N:24])[c:8](-[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[c:9]2[cH:10][c:11]([O:15][CH3:16])[cH:12][cH:13][c:14]12)[CH:3]=[CH2:4].[OH:25][CH:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1>>[c:5]1([N:29]2[CH2:28][CH2:27][CH:26]([OH:25])[CH2:31][CH2:30]2)[n:6][c:7]([C:23]#[N:24])[c:8](-[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[c:9]2[cH:10][c:11]([O:15][CH3:16])[cH:12][cH:13][c:14]12Participants
3
Sources & evidence
- ORD record
- ord-9a103b2df7494d9b85f865c8b17c1e59
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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