2-(Trimethylsilyl)ethyl chloroformate → beta-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-yl-methoxy]-piperidine-1-carboxylate

HRID 957114Notes

Reaction equation

HRID 957114 reaction equation
[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[N:18]1[CH2:19][CH:20]([O:31][CH2:32][c:33]2[cH:34][c:35]3[cH:36][cH:37][cH:38][cH:39][c:40]3[c:41]([O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:49])([CH3:50])[CH3:51])[cH:42]2)[CH:21]([c:24]2[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]2)[CH2:22][CH2:23]1.[Cl:1][C:2](=[O:3])[O:4][CH2:5][CH2:6][Si:7]([CH3:8])([CH3:9])[CH3:10]>>[C:2](=[O:3])([O:4][CH2:5][CH2:6][Si:7]([CH3:8])([CH3:9])[CH3:10])[N:18]1[CH2:19][CH:20]([O:31][CH2:32][c:33]2[cH:34][c:35]3[cH:36][cH:37][cH:38][cH:39][c:40]3[c:41]([O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:49])([CH3:50])[CH3:51])[cH:42]2)[CH:21]([c:24]2[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]2)[CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 109101682-(Trimethylsilyl)ethyl chloroformateHCID 22127049(3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine

Product 1

HCID 86604391beta-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-yl-methoxy]-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-93ba0ea2e9284c8b85342fd69c6623a0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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