Hydrochloric Acid → Dimethyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-YL)ethyl]-2,5-piperidinedicarboxylate

HRID 957152Notes

Reaction equation

HRID 957152 reaction equation
[CH2:44]([Cl:45])[Cl:46].[CH3:8][O:9][C:10](=[O:11])[CH:12]1[NH:13][CH2:14][CH:15]([C:18](=[O:19])[O:20][CH3:21])[CH2:16][CH2:17]1.[ClH:7].[Na+:1].[Na+:2].[O-:3][C:4](=[O:5])[O-:6].[OH2:43].[S:22]([O:23][CH2:30][CH2:31][N:32]1[C:33](=[O:42])[c:34]2[c:35]([cH:38][cH:39][cH:40][cH:41]2)[C:36]1=[O:37])([C:24]([F:25])([F:26])[F:27])(=[O:28])=[O:29]>>[CH3:8][O:9][C:10](=[O:11])[CH:12]1[N:13]([CH2:30][CH2:31][N:32]2[C:33](=[O:42])[c:34]3[c:35]([cH:38][cH:39][cH:40][cH:41]3)[C:36]2=[O:37])[CH2:14][CH:15]([C:18](=[O:19])[O:20][CH3:21])[CH2:16][CH2:17]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 962WaterHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 118094652-(1,3-Dioxoisoindolin-2-yl)ethyl trifluoromethanesulfonateHCID 134130932,5-Dimethyl piperidine-2,5-dicarboxylate

Product 1

HCID 19043467Dimethyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-YL)ethyl]-2,5-piperidinedicarboxylate

Sources & evidence

ORD record
ord-7674750ea30040399aaa3a3e74ed5720
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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