Dimethyl Sulfoxide → Tert-butyl 4-(3-methyl-4-nitrophenyl)piperazine-1-carboxylate

HRID 957732Notes

Reaction equation

HRID 957732 reaction equation
[C:12]([CH3:13])([CH3:14])([CH3:15])[O:16][C:17](=[O:18])[N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1.[C:25](=[O:26])([O-:27])[O-:28].[CH3:31][S:32](=[O:33])[CH3:34].[CH3:35][CH2:36][O:37][C:38](=[O:39])[CH3:40].[F:1][c:2]1[cH:3][c:4]([CH3:11])[c:5]([N+:8](=[O:9])[O-:10])[cH:6][cH:7]1.[K+:29].[K+:30]>>[c:2]1([N:22]2[CH2:21][CH2:20][N:19]([C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])[CH2:24][CH2:23]2)[cH:3][c:4]([CH3:11])[c:5]([N+:8](=[O:9])[O-:10])[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 949565-Fluoro-2-nitrotolueneHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 53763997Tert-butyl 4-(3-methyl-4-nitrophenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-c208187d055e4184b0eeaade44329d80
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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