Tetrahydrofuran → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 957887Notes

Reaction equation

HRID 957887 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][CH:14]([OH:15])[CH2:16]1.[CH2:17]1[O:18][CH2:19][CH2:20][CH2:21]1.[CH2:22]([CH3:23])[O:24][C:25](=[O:26])[C:27]1([NH2:32])[CH:28]([CH:30]=[CH2:31])[CH2:29]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:12])[NH:32][C:27]2([C:25]([O:24][CH2:22][CH3:23])=[O:26])[CH:28]([CH:30]=[CH2:31])[CH2:29]2)[CH2:13][CH:14]([OH:15])[CH2:16]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 3352551-((Tert-butoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acidHCID 22082824Ethyl 1-amino-2-vinylcyclopropanecarboxylate

Product 1

HCID 235716032-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-bef12d5fa4c042a89de0123e18cca8bc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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