Toluene → 8,10a-Dihydro-7,9-dimethyl-6-oxo-6H-pyrano(3,2-b:5,4-c') dipyridine-10-carboxylic acid ethyl ester

HRID 957946Notes

Reaction equation

HRID 957946 reaction equation
[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[CH3:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1.[N:26]12[CH2:27][CH2:28][CH2:29][CH:30]=[C:31]1[CH2:32][CH2:33][CH2:34][CH2:35][NH:36]2.[OH:1][c:2]1[c:3]([CH:8]2[C:9]([C:21]([O:23][CH2:22][CH3:24])=[O:25])=[C:10]([CH3:20])[NH:11][C:12]([CH3:19])=[C:13]2[C:14](=[O:15])[O:16][CH2:17][CH3:18])[n:4][cH:5][cH:6][cH:7]1>>[O:1]1[c:2]2[c:3]([n:4][cH:5][cH:6][cH:7]2)[CH:8]2[C:9](=[C:10]([CH3:20])[NH:11][C:12]([CH3:19])=[C:13]2[C:14](=[O:15])[O:16][CH2:17][CH3:18])[C:21]1=[O:23]

Participants

5

Reactant 4

HCID 1140TolueneHCID 8857Ethyl AcetateHCID 9834010Diazabicyclo[5.4.0]undec-7-eneHCID 13374597Diethyl 1,4-dihydro-4-(3-hydroxypyridyl)-2,6-dimethyl-3,5-pyridine dicarboxylate

Product 1

HCID 133745998,10a-Dihydro-7,9-dimethyl-6-oxo-6H-pyrano(3,2-b:5,4-c') dipyridine-10-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-21c69abbebf14444855f7cfd45840341
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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