Acetate → 1-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazine

HRID 958045Notes

Reaction equation

HRID 958045 reaction equation
[Br:1][c:2]1[c:3]([F:11])[cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1.[C:31]([O-:32])(=[O:33])[CH3:34].[C:36]([O-:37])(=[O:38])[CH3:39].[CH2:18]1[CH2:19][NH:20][CH2:21][CH2:22][NH:23]1.[CH3:12][C:13]([CH3:14])([O-:15])[CH3:16].[CH3:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[Na+:17].[Pd+2:35]>>[c:2]1([N:20]2[CH2:19][CH2:18][NH:23][CH2:22][CH2:21]2)[c:3]([F:11])[cH:4][c:5]([Cl:10])[c:6]([O:8][CH3:9])[cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 923Sodium ionHCID 1140TolueneHCID 4837PiperazineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 45749132-Methylpropan-2-olateHCID 102203785-bromo-2-chloro-4-fluoroanisole

Product 1

HCID 576427921-(4-Chloro-2-fluoro-5-methoxyphenyl)piperazine

Sources & evidence

ORD record
ord-95f17a1d47e240fabaa9730037db5bc7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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