Sodium ion → 4-(3-Methoxy-phenyl)-7-[2-(4-methyl-piperazin-1-yl)-pyridin-4-yl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

HRID 958613Notes

Reaction equation

HRID 958613 reaction equation
[CH3:8][N:9]1[CH2:10][CH2:11][N:12]([c:15]2[n:16][cH:17][cH:18][c:19]([NH2:21])[cH:20]2)[CH2:13][CH2:14]1.[Cl:22][c:23]1[n:24][c:25]([N:40]2[CH2:41][CH2:42][O:43][CH2:44][CH2:45]2)[n:26][c:27](-[c:32]2[cH:33][c:34]([O:38][CH3:39])[cH:35][cH:36][cH:37]2)[c:28]1[CH2:29][CH2:30][Cl:31].[H-:1].[Na+:2].[O:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1.[OH2:46]>>[CH3:8][N:9]1[CH2:10][CH2:11][N:12]([c:15]2[n:16][cH:17][cH:18][c:19]([N:21]3[c:23]4[n:24][c:25]([N:40]5[CH2:41][CH2:42][O:43][CH2:44][CH2:45]5)[n:26][c:27](-[c:32]5[cH:33][c:34]([O:38][CH3:39])[cH:35][cH:36][cH:37]5)[c:28]4[CH2:29][CH2:30]3)[cH:20]2)[CH2:13][CH2:14]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 166653HydrideHCID 118391892-(4-Methylpiperazin-1-yl)pyridin-4-amineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholine

Product 1

HCID 592449894-(3-Methoxy-phenyl)-7-[2-(4-methyl-piperazin-1-yl)-pyridin-4-yl]-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-70ba98d2b7d54a4c9fea40d0c7fc1130
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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