Water → benzyl 4-{[(1-tetrahydro-2H-pyran-2-yl-1H-indazol-5-yl)amino]sulfonyl}-1-piperidinecarboxylate

HRID 958722Notes

Reaction equation

HRID 958722 reaction equation
[CH2:45]([Cl:46])[Cl:47].[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:24][S:25](=[O:26])(=[O:27])[CH:28]1[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][CH2:37][c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[CH2:32][CH2:33]1.[O:8]1[CH:9]([n:14]2[n:15][cH:16][c:17]3[cH:18][c:19]([NH2:23])[cH:20][cH:21][c:22]23)[CH2:10][CH2:11][CH2:12][CH2:13]1.[OH2:44]>>[O:8]1[CH:9]([n:14]2[n:15][cH:16][c:17]3[cH:18][c:19]([NH:23][S:25](=[O:26])(=[O:27])[CH:28]4[CH2:29][CH2:30][N:31]([C:34](=[O:35])[O:36][CH2:37][c:38]5[cH:39][cH:40][cH:41][cH:42][cH:43]5)[CH2:32][CH2:33]4)[cH:20][cH:21][c:22]23)[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 21931260Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylateHCID 229339271-(Oxan-2-yl)-1H-indazol-5-amine

Product 1

HCID 69431167benzyl 4-{[(1-tetrahydro-2H-pyran-2-yl-1H-indazol-5-yl)amino]sulfonyl}-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-380e46a3bffc434898525d27b6f76c2b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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