Dichloromethane → 5-(2-aminoethyl)-N-{3-methyl-4-[3-(trifluoromethoxy)phenoxy]phenyl}-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Reaction equation
[CH3:1][c:2]1[cH:3][c:4]([NH:20][c:21]2[c:22]3[c:23]([n:24][cH:25][n:26]2)[cH:27][cH:28][n:29]3[CH2:30][CH2:31][NH:32][C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][c:11]([O:15][C:16]([F:17])([F:18])[F:19])[cH:12][cH:13][cH:14]1.[Cl:47][CH2:48][Cl:49].[OH:40][C:41]([C:42]([F:43])([F:44])[F:45])=[O:46]>>[CH3:1][c:2]1[cH:3][c:4]([NH:20][c:21]2[c:22]3[c:23]([n:24][cH:25][n:26]2)[cH:27][cH:28][n:29]3[CH2:30][CH2:31][NH2:32])[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][c:11]([O:15][C:16]([F:17])([F:18])[F:19])[cH:12][cH:13][cH:14]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-89da99b02caa460594a4a221b7264a8b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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