Bicarbonate Ion → (4-Morpholin-4-ylmethyl-phenyl)piperazin-1-yl-methanone

HRID 958827Notes

Reaction equation

HRID 958827 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([C:14]([c:15]2[cH:16][cH:17][c:18]([CH2:21][N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[cH:19][cH:20]2)=[O:28])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:36][CH2:37][Cl:38].[Na+:43].[O-:39][C:40]([OH:41])=[O:42].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH2:9][CH2:10][N:11]([C:14]([c:15]2[cH:16][cH:17][c:18]([CH2:21][N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)[cH:19][cH:20]2)=[O:28])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 592181854-(4-Morpholin-4-ylmethyl-benzoyl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 59218186(4-Morpholin-4-ylmethyl-phenyl)piperazin-1-yl-methanone

Sources & evidence

ORD record
ord-980e7bc78fbb4832bba5f5912ea53955
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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