Chloride → 4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

HRID 958851Notes

Reaction equation

HRID 958851 reaction equation
[Al+3:27].[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:10]1)[CH2:7][CH2:8][O:9]2.[CH2:11]([CH3:12])[O:13][C:14]([C:15]([CH2:16][C:17](=[CH2:18])[CH3:19])([C:20]([F:21])([F:22])[F:23])[OH:24])=[O:25].[Cl-:26].[Cl-:28].[Cl-:29].[S:30]=[C:31]=[S:32]>>[Br:1][c:2]1[cH:3][c:4]([C:17]([CH2:16][C:15]([C:14]([O:13][CH2:11][CH3:12])=[O:25])([C:20]([F:21])([F:22])[F:23])[OH:24])([CH3:18])[CH3:19])[c:5]2[c:6]([cH:10]1)[CH2:7][CH2:8][O:9]2

Participants

6

Reactant 5

HCID 312Chloride3×HCID 6348Carbon DisulfideHCID 104727Aluminum CationHCID 27761595-Bromo-2,3-dihydro-1-benzofuranHCID 17935595Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate

Product 1

HCID 589599534-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

Sources & evidence

ORD record
ord-1e8809f898564cf58647e3efffcd5a56
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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