Trifluoroacetic acid → 4-amino-N-(1-(4-chlorophenyl)-2-(methylsulfonamido)ethyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

HRID 959122Notes

Reaction equation

[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][NH:10][S:11](=[O:12])(=[O:13])[CH3:14])[NH:15][C:16](=[O:17])[C:18]2([NH:33][C:34](=[O:35])[O:36][C:37]([CH3:38])([CH3:39])[CH3:40])[CH2:19][CH2:20][N:21]([c:24]3[c:25]4[c:26]([n:27][cH:28][n:29]3)[nH:30][cH:31][cH:32]4)[CH2:22][CH2:23]2)[cH:6][cH:7]1.[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][NH:10][S:11](=[O:12])(=[O:13])[CH3:14])[NH:15][C:16](=[O:17])[C:18]2([NH2:33])[CH2:19][CH2:20][N:21]([c:24]3[c:25]4[c:26]([n:27][cH:28][n:29]3)[nH:30][cH:31][cH:32]4)[CH2:22][CH2:23]2)[cH:6][cH:7]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 57750276Tert-butyl 4-(1-(4-chlorophenyl)-2-(methylsulfonamido)ethylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Product 1

HCID 577503114-amino-N-(1-(4-chlorophenyl)-2-(methylsulfonamido)ethyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Sources & evidence

ORD record: ord-53cf79b1c0374b06b3a9fbf504220e7c
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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