Chloroform → 2-[4-[2-Fluoro-4-(trifluoromethoxy)phenyl]sulfonyl-3-[(4-propylphenyl)methylcarbamoyl]piperazin-1-yl]-4-methyl-1,3-thiazole-5-carboxylic acid
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[c:9]([CH3:47])[n:10][c:11]([N:13]2[CH2:14][CH:15]([C:34]([NH:35][CH2:36][c:37]3[cH:38][cH:39][c:40]([CH2:43][CH2:44][CH3:45])[cH:41][cH:42]3)=[O:46])[N:16]([S:19](=[O:20])(=[O:21])[c:22]3[c:23]([F:33])[cH:24][c:25]([O:28][C:29]([F:30])([F:31])[F:32])[cH:26][cH:27]3)[CH2:17][CH2:18]2)[s:12]1.[CH:55]([Cl:56])([Cl:57])[Cl:58].[OH:48][C:49]([C:50]([F:51])([F:52])[F:53])=[O:54]>>[O:5]=[C:6]([OH:7])[c:8]1[c:9]([CH3:47])[n:10][c:11]([N:13]2[CH2:14][CH:15]([C:34]([NH:35][CH2:36][c:37]3[cH:38][cH:39][c:40]([CH2:43][CH2:44][CH3:45])[cH:41][cH:42]3)=[O:46])[N:16]([S:19](=[O:20])(=[O:21])[c:22]3[c:23]([F:33])[cH:24][c:25]([O:28][C:29]([F:30])([F:31])[F:32])[cH:26][cH:27]3)[CH2:17][CH2:18]2)[s:12]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-980efa35db7f437487c96b4191d9b25a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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