Bromide ion → Methyl 5-(difluoromethoxy)-2-methylbenzoate

HRID 959538Notes

Reaction equation

HRID 959538 reaction equation
[Br-:19].[CH3:20][CH2:21][CH2:22][CH2:23][N+:24]([CH2:25][CH2:26][CH2:27][CH3:28])([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:33][CH2:34][CH2:35][CH3:36].[Cl:1][CH:2]([F:3])[F:4].[Na+:18].[O:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1.[OH-:17].[OH:5][c:6]1[cH:7][cH:8][c:9]([CH3:16])[c:10]([C:11](=[O:12])[O:13][CH3:14])[cH:15]1>>[CH:2]([F:3])([F:4])[O:5][c:6]1[cH:7][cH:8][c:9]([CH3:16])[c:10]([C:11](=[O:12])[O:13][CH3:14])[cH:15]1

Participants

8

Reactant 7

HCID 259Bromide ionHCID 923Sodium ionHCID 961HydroxideHCID 6372ChlorodifluoromethaneHCID 16028TetrabutylammoniumHCID 312751,4-DioxaneHCID 13929055Methyl 5-hydroxy-2-methylbenzoate

Product 1

HCID 53418071Methyl 5-(difluoromethoxy)-2-methylbenzoate

Sources & evidence

ORD record
ord-65ddc529fc6640c6b08599ce6c291723
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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