Nitric Acid → 1,5-Difluoro-3-methoxy-2-nitrobenzene

HRID 959572Notes

Reaction equation

HRID 959572 reaction equation
[CH3:16][CH2:17][O:18][C:19](=[O:20])[CH3:21].[Cl:22][CH2:23][Cl:24].[F:1][c:2]1[cH:3][c:4]([O:9][CH3:10])[cH:5][c:6]([F:8])[cH:7]1.[OH2:15].[OH:11][N+:12]([O-:13])=[O:14]>>[F:1][c:2]1[c:3]([N+:12](=[O:11])[O-:13])[c:4]([O:9][CH3:10])[cH:5][c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 944Nitric AcidHCID 962WaterHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 27245183,5-Difluoroanisole

Product 1

HCID 103301291,5-Difluoro-3-methoxy-2-nitrobenzene

Sources & evidence

ORD record
ord-f57e647f6d6d45bcbd19382072e427b1
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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