Methanol → 2-(5-(4,5-Diamino-2-fluoro-3-(tetrahydrofuran-2-yl)phenyl)pyrimidin-2-yl)propan-2-ol
Reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:1][OH:2].[NH2:3][c:4]1[c:5]([CH:24]2[O:25][CH2:26][CH2:27][CH2:28]2)[c:6]([F:23])[c:7](-[c:13]2[cH:14][n:15][c:16]([C:19]([CH3:20])([CH3:21])[OH:22])[n:17][cH:18]2)[cH:8][c:9]1[N+:10]([O-:11])=[O:12]>>[NH2:3][c:4]1[c:5]([CH:24]2[O:25][CH2:26][CH2:27][CH2:28]2)[c:6]([F:23])[c:7](-[c:13]2[cH:14][n:15][c:16]([C:19]([CH3:20])([CH3:21])[OH:22])[n:17][cH:18]2)[cH:8][c:9]1[NH2:10]Participants
4
Sources & evidence
- ORD record
- ord-620408206322426da28944aa67f1743b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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