Dichloromethane → 7-[2-(4-Fluoro-benzylamino)-benzoylamino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

HRID 959919Notes

Reaction equation

HRID 959919 reaction equation
[B-:39]([F:40])([F:41])([F:42])[F:43].[C:19]([CH3:20])([CH3:21])([CH3:22])[O:23][C:24](=[O:25])[N:26]1[CH2:27][c:28]2[cH:29][c:30]([NH2:38])[cH:31][cH:32][c:33]2[C:34]([CH3:36])([CH3:37])[CH2:35]1.[CH:61]([N:62]([CH2:63][CH3:64])[CH:65]([CH3:66])[CH3:67])([CH3:68])[CH3:69].[Cl:70][CH2:71][Cl:72].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][c:8]2[c:9]([C:10](=[O:11])[OH:12])[cH:13][cH:14][cH:15][cH:16]2)[cH:17][cH:18]1.[n:44]1([O:45][C:46]([N:47]([CH3:48])[CH3:49])=[N+:50]([CH3:51])[CH3:52])[c:53]2[cH:54][cH:55][cH:56][cH:57][c:58]2[n:59][n:60]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][c:8]2[c:9]([C:10](=[O:12])[NH:38][c:30]3[cH:29][c:28]4[c:33]([cH:32][cH:31]3)[C:34]([CH3:36])([CH3:37])[CH2:35][N:26]([C:24]([O:23][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:25])[CH2:27]4)[cH:13][cH:14][cH:15][cH:16]2)[cH:17][cH:18]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 21786232HCID 21786232, compoundHCID 21959561Tert-butyl 7-amino-4,4-dimethyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Product 1

HCID 695108657-[2-(4-Fluoro-benzylamino)-benzoylamino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-0c2d45aa70ff4ba3a0526955d5d4070a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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