Pyridine → 3-[(RS)-1-(5-Chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-dichloro-phenyl)-pyrrolidine-1-carbonyl chloride

HRID 959994Notes

Reaction equation

HRID 959994 reaction equation
[Cl:13][c:14]1[cH:15][cH:16][c:17]([O:20][CH:21]([CH3:22])[CH:23]2[CH2:24][NH:25][CH2:26][CH:27]2[c:28]2[cH:29][c:30]([Cl:35])[c:31]([Cl:34])[cH:32][cH:33]2)[n:18][cH:19]1.[Cl:1][C:2]([Cl:3])([O:4][C:5]([O:6][C:7]([Cl:9])([Cl:10])[Cl:11])=[O:8])[Cl:12].[Cl:42][CH2:43][Cl:44].[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[O:6]=[C:7]([Cl:10])[N:25]1[CH2:24][CH:23]([CH:21]([O:20][c:17]2[cH:16][cH:15][c:14]([Cl:13])[cH:19][n:18]2)[CH3:22])[CH:27]([c:28]2[cH:29][c:30]([Cl:35])[c:31]([Cl:34])[cH:32][cH:33]2)[CH2:26]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 94429TriphosgeneHCID 669991845-Chloro-2-{(RS)-1-[(3SR,4RS)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethoxy}-pyridine

Product 1

HCID 866281803-[(RS)-1-(5-Chloro-pyridin-2-yloxy)-ethyl]-4-(3,4-dichloro-phenyl)-pyrrolidine-1-carbonyl chloride

Sources & evidence

ORD record
ord-13e3d7cd3abb4f6b8254312498999ff3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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