Dimethyl Sulfoxide → tert-Butyl 3-oxo-2-phenylpiperidine-1-carboxylate

HRID 960090Notes

Reaction equation

HRID 960090 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH:24]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[CH:25]([OH:29])[CH2:26][CH2:27][CH2:28]1.[CH3:1][S:2](=[O:3])[CH3:4].[CH3:5][N:6]([CH3:7])[CH2:8][CH2:9][CH2:10][N:11]=[C:12]=[N:13][CH2:14][CH3:15].[Cl:42][CH2:43][Cl:44].[cH:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1>>[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH:24]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[C:25](=[O:29])[CH2:26][CH2:27][CH2:28]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 1049PyridineHCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 215840931-t-Butyloxycarbonyl-3-hydroxy-2-phenylpiperidine

Product 1

HCID 11414684tert-Butyl 3-oxo-2-phenylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-489f115f98094307a5dc852ea75911ce
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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