Dichloromethane → Methanesulfonic acid 1-[1-(4-Chloro-phenyl)-cyclopentanecarbonyl]-piperidin-3-ylmethyl ester

HRID 960212Notes

Reaction equation

HRID 960212 reaction equation
[CH3:32][S:33]([Cl:34])(=[O:35])=[O:36].[CH:23]([N:24]([CH2:25][CH3:26])[CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:13](=[O:14])[N:15]3[CH2:16][CH:17]([CH2:21][OH:22])[CH2:18][CH2:19][CH2:20]3)[CH2:9][CH2:10][CH2:11][CH2:12]2)[cH:6][cH:7]1.[Cl:37][CH2:38][Cl:39]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:13](=[O:14])[N:15]3[CH2:16][CH:17]([CH2:21][O:22][S:33]([CH3:32])(=[O:35])=[O:36])[CH2:18][CH2:19][CH2:20]3)[CH2:9][CH2:10][CH2:11][CH2:12]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 22335026[1-(4-Chloro-phenyl)-cyclopentyl]-(3-hydroxymethyl-piperidin-1-yl)-methanone

Product 1

HCID 21303199Methanesulfonic acid 1-[1-(4-Chloro-phenyl)-cyclopentanecarbonyl]-piperidin-3-ylmethyl ester

Sources & evidence

ORD record
ord-0247cf7c70ea46acb14c7a74908aa864
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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