Acetone → 3-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)-1-isopropylazetidine-3-carboxamide

HRID 960349Notes

Reaction equation

[CH3:33][C:34]([CH3:35])=[O:36].[Cl:2][c:3]1[c:4]([F:32])[c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:30][CH3:31])[c:17]([CH2:20][N:21]([C:22]4([C:26](=[O:27])[NH2:28])[CH2:23][NH:24][CH2:25]4)[CH3:29])[cH:18][c:19]23)[cH:6][cH:7][cH:8]1.[ClH:1]>>[Cl:2][c:3]1[c:4]([F:32])[c:5]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:30][CH3:31])[c:17]([CH2:20][N:21]([C:22]4([C:26](=[O:27])[NH2:28])[CH2:23][N:24]([CH:34]([CH3:33])[CH3:35])[CH2:25]4)[CH3:29])[cH:18][c:19]23)[cH:6][cH:7][cH:8]1

Participants

Reactant 3

HCID 180Acetone

HCID 313Hydrochloric Acid

HCID 579798103-[({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)(methyl)amino]azetidine-3-carboxamide

Product 1

HCID 115621713-(((4-(3-Chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)(methyl)amino)-1-isopropylazetidine-3-carboxamide

Sources & evidence

ORD record: ord-cc0f376457d44386b00915dcc45e955a
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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