Acetate → (4-Trifluoromethyl-phenyl)-[2-(2-triisopropylsilanylsulfanyl-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-amine
Reaction equation
[C:48](=[O:49])([O-:50])[O-:51].[C:65]([O-:66])(=[O:67])[CH3:68].[C:70]([O-:71])(=[O:72])[CH3:73].[CH3:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1.[CH:54]([CH3:55])([CH3:56])[Si:57]([SH:58])([CH:59]([CH3:60])[CH3:61])[CH:62]([CH3:63])[CH3:64].[Cs+:52].[Cs+:53].[I:1][c:2]1[c:3]([CH2:4][c:5]2[s:6][c:7]3[n:8][cH:9][n:10][c:11]([NH:14][c:15]4[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]4)[c:12]3[n:13]2)[cH:25][cH:26][cH:27][cH:28]1.[Pd+2:69].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[c:2]1([S:58][Si:57]([CH:54]([CH3:55])[CH3:56])([CH:59]([CH3:60])[CH3:61])[CH:62]([CH3:63])[CH3:64])[c:3]([CH2:4][c:5]2[s:6][c:7]3[n:8][cH:9][n:10][c:11]([NH:14][c:15]4[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]4)[c:12]3[n:13]2)[cH:25][cH:26][cH:27][cH:28]1Participants
9
Reactant 8
HCID 175Acetate2×
HCID 1140Toluene
HCID 11776Triphenylphosphine
HCID 19660Carbonate Ion
HCID 104967Cesium cation2×
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 3435097Tris(propan-2-yl)silanethiol
HCID 42622946[2-(2-Iodo-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amineProduct 1
Sources & evidence
- ORD record
- ord-5c56468a121242be8ae64d134dbe7c86
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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