Chloroform → 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperidine-1-carboxylic acid (4-iodo-phenyl)-amide

HRID 960395Notes

Reaction equation

HRID 960395 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14].[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:50][CH:51]([Cl:52])[Cl:53].[Cl:54][CH2:55][Cl:56].[N+:21]([c:22]1[cH:23][cH:24][c:25]([O:30][C:31](=[O:26])[NH:32][c:33]2[cH:34][cH:35][c:36]([I:39])[cH:37][cH:38]2)[cH:27][cH:28]1)([O-:29])=[O:40]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([CH:15]3[CH2:16][CH2:17][N:18]([C:31](=[O:30])[NH:32][c:33]4[cH:34][cH:35][c:36]([I:39])[cH:37][cH:38]4)[CH2:19][CH2:20]3)[n:7][cH:8][n:9][c:10]2[cH:11][c:12]1[O:13][CH3:14]

Participants

6

Reactant 5

HCID 6212ChloroformHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 4060865(4-Iodo-phenyl)-carbamic acid 4-nitro-phenyl esterHCID 595517346,7-Dimethoxy-4-(piperidin-4-yl)quinazoline

Product 1

HCID 587707304-(6,7-Dimethoxy-quinazolin-4-yl)-piperidine-1-carboxylic acid (4-iodo-phenyl)-amide

Sources & evidence

ORD record
ord-927619fbe76b4eb5a66237cf46a45930
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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