Bicarbonate Ion → 1-(4-Chlorobenzyl)-7-cyclohexyl-1,7-diazaspiro[4.4]nonane-3,6-dione

HRID 960594Notes

Reaction equation

HRID 960594 reaction equation
[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH:9]([OH:23])[CH2:10][C:11]23[C:12](=[O:22])[N:13]([CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:14][CH2:15]3)[cH:24][cH:25]1.[Cl:26][CH2:27][Cl:28].[Na+:29].[Na+:30].[Na+:40].[O-:31][S:32]([O-:33])(=[S:34])=[O:35].[O-:36][C:37]([OH:38])=[O:39]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][C:9](=[O:23])[CH2:10][C:11]23[C:12](=[O:22])[N:13]([CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:14][CH2:15]3)[cH:24][cH:25]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ion3×HCID 1084Thiosulfate ionHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 673561901-[(4-Chlorophenyl)methyl]-7-cyclohexyl-3-hydroxy-1,7-diazaspiro[4.4]nonan-6-one

Product 1

HCID 673556101-(4-Chlorobenzyl)-7-cyclohexyl-1,7-diazaspiro[4.4]nonane-3,6-dione

Sources & evidence

ORD record
ord-4ac933f4bf054fdcbf12a25c68347b4e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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