1-(Bromomethyl)-4-(trifluoromethyl)benzene → ethyl 2-(1-(4-(difluoromethoxy)benzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylate
Reaction equation
[Br:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([O:21][CH:22]([F:23])[F:24])[cH:19][cH:20]1.[CH3:25][c:26]1[n:27][c:28](-[n:36]2[cH:37][n:38][nH:39][c:40]2=[O:41])[s:29][c:30]1[C:31](=[O:32])[O:33][CH2:34][CH3:35].[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][Br:10])[cH:11][cH:12]1>>[CH2:14]([c:15]1[cH:16][cH:17][c:18]([O:21][CH:22]([F:23])[F:24])[cH:19][cH:20]1)[n:39]1[n:38][cH:37][n:36](-[c:28]2[n:27][c:26]([CH3:25])[c:30]([C:31](=[O:32])[O:33][CH2:34][CH3:35])[s:29]2)[c:40]1=[O:41]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-0341690d08df4ca9978fe534f4bb9e63
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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