Acetic Acid → 2-Chloro-4-(trifluoromethyl)benzaldehyde

HRID 960886Notes

Reaction equation

HRID 960886 reaction equation
[CH3:14][CH:15]([CH2:16][AlH:17][CH2:18][CH:19]([CH3:20])[CH3:21])[CH3:22].[CH3:23][C:24]([OH:25])=[O:26].[CH3:28][c:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1.[Cl:1][c:2]1[c:3]([C:4]#[N:5])[cH:6][cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1.[OH2:27]>>[Cl:1][c:2]1[c:3]([CH:4]=[O:25])[cH:6][cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 962WaterHCID 1140TolueneHCID 14487Diisobutylaluminum hydrideHCID 27364762-Chloro-4-(trifluoromethyl)benzonitrile

Product 1

HCID 130761442-Chloro-4-(trifluoromethyl)benzaldehyde

Sources & evidence

ORD record
ord-5d23c52145914ce5ab6d4f76e4b3f795
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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