Sodium ion → Tert-butyl 4-(3-bromophenoxy)-2-methylpiperidine-1-carboxylate

HRID 961128Notes

Reaction equation

HRID 961128 reaction equation
[Br:18][c:19]1[cH:20][c:21]([F:25])[cH:22][cH:23][cH:24]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH3:15])[CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[H-:16].[Na+:17].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH3:15])[CH2:10][CH:11]([O:14][c:21]2[cH:20][c:19]([Br:18])[cH:24][cH:23][cH:22]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 140821-Bromo-3-fluorobenzeneHCID 166653HydrideHCID 22181172Tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate

Product 1

HCID 69063263Tert-butyl 4-(3-bromophenoxy)-2-methylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-28f074085f9146b69b8c82e61e3a5351
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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