Acetonitrile → Ethyl 1-(benzyloxycarbonylmethyl)isonipecotate

HRID 961164Notes

Reaction equation

HRID 961164 reaction equation
[Br:12][CH2:13][C:14](=[O:15])[O:16][CH2:17][c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1.[C:24](=[O:25])([O-:26])[O-:27].[CH3:30][C:31]#[N:32].[Cs+:28].[Cs+:29].[NH:1]1[CH2:2][CH2:3][CH:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[CH2:10][CH2:11]1>>[N:1]1([CH2:13][C:14](=[O:15])[O:16][CH2:17][c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[CH2:2][CH2:3][CH:4]([C:5](=[O:6])[O:7][CH2:8][CH3:9])[CH2:10][CH2:11]1

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 19660Carbonate IonHCID 62576Benzyl bromoacetateHCID 70770Ethyl 4-piperidinecarboxylateHCID 104967Cesium cation2×

Product 1

HCID 22716663Ethyl 1-(benzyloxycarbonylmethyl)isonipecotate

Sources & evidence

ORD record
ord-68ab11af5cec4898a5cbc7621bbd95da
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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