Diisopropylamine → 2-Acetyl-4-(4-pyridyl)cyclohexanone

HRID 961180Notes

Reaction equation

HRID 961180 reaction equation
[C:19]([CH3:20])(=[O:21])[c:22]1[nH:23][cH:24][cH:25][n:26]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44].[CH:32]([NH:33][CH:34]([CH3:35])[CH3:36])([CH3:37])[CH3:38].[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1.[n:6]1[cH:7][cH:8][c:9]([CH:12]2[CH2:13][CH2:14][C:15](=[O:18])[CH2:16][CH2:17]2)[cH:10][cH:11]1>>[n:6]1[cH:7][cH:8][c:9]([CH:12]2[CH2:13][CH:14]([C:19]([CH3:20])=[O:21])[C:15](=[O:18])[CH2:16][CH2:17]2)[cH:10][cH:11]1

Participants

7

Reactant 6

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 5389722-AcetylimidazoleHCID 10154273Cyclohexanone, 4-(4-pyridinyl)-HCID 178418339Butyllithium

Product 1

HCID 137720552-Acetyl-4-(4-pyridyl)cyclohexanone

Sources & evidence

ORD record
ord-5fd7f28ec36b4dc0aff00ce28e1eb586
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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