Dichloromethane → 6-amino-9-(3-aminophenyl)-7-(4-chlorophenyl)-7H-purin-8(9H)-one

HRID 961376Notes

Reaction equation

HRID 961376 reaction equation
[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39].[NH2:1][c:2]1[c:3]2[n:4](-[c:26]3[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]3)[c:5](=[O:25])[n:6](-[c:11]3[cH:12][c:13]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[cH:14][cH:15][cH:16]3)[c:7]2[n:8][cH:9][n:10]1>>[NH2:1][c:2]1[c:3]2[n:4](-[c:26]3[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]3)[c:5](=[O:25])[n:6](-[c:11]3[cH:12][c:13]([NH2:17])[cH:14][cH:15][cH:16]3)[c:7]2[n:8][cH:9][n:10]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86691214tert-butyl 3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenylcarbamate

Product 1

HCID 866912156-amino-9-(3-aminophenyl)-7-(4-chlorophenyl)-7H-purin-8(9H)-one

Sources & evidence

ORD record
ord-a4a52b4b22f347059fad6cbf970e9860
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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