Dichloromethane → 5-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole

HRID 961589Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][c:20]4[cH:21][cH:22][c:23]([Br:28])[cH:24][c:25]4[cH:26][cH:27]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][c:20]4[cH:21][cH:22][c:23]([Br:28])[cH:24][c:25]4[cH:26][cH:27]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58185449tert-butyl (2S)-2-[5-(6-bromonaphthalen-2-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

Product 1

HCID 666207675-(6-Bromo-naphthalen-2-yl)-2-pyrrolidin-2-yl-1H-imidazole

Sources & evidence

ORD record: ord-33a8ea9c4b6443849ebbb8747e21f0e1
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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