1-(4-(6-(4-Methoxybenzylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea → tert-butyl N-[1-[3-[4-[2-fluoro-4-[[2-(4-fluorophenyl)acetyl]carbamoylamino]phenoxy]-3-pyridinyl]prop-2-enoyl]piperidin-4-yl]carbamate
Reaction equation
[CH3:47][O:48][c:49]1[cH:50][cH:51][c:52]([CH2:53][NH:54][c:55]2[n:56][cH:57][n:58][c:59]([O:60][c:61]3[cH:62][cH:63][c:64]([NH:65][C:66]([NH:67][C:68](=[O:69])[CH2:70][c:71]4[cH:72][cH:73][c:74]([F:75])[cH:76][cH:77]4)=[O:78])[cH:79][c:80]3[F:81])[cH:82]2)[cH:83][cH:84]1.[F:34][c:35]1[cH:36][cH:37][c:38]([CH2:41][C:42](=[O:43])[N:44]=[C:45]=[O:46])[cH:39][cH:40]1.[NH2:1][c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[c:8]([CH:13]=[CH:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][CH:20]([NH:23][C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:21][CH2:22]3)[cH:9][n:10][cH:11][cH:12]2)[cH:31][cH:32]1>>[NH:1]([c:2]1[cH:3][c:4]([F:33])[c:5]([O:6][c:7]2[c:8]([CH:13]=[CH:14][C:15](=[O:16])[N:17]3[CH2:18][CH2:19][CH:20]([NH:23][C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:21][CH2:22]3)[cH:9][n:10][cH:11][cH:12]2)[cH:31][cH:32]1)[C:45]([NH:44][C:42]([CH2:41][c:38]1[cH:37][cH:36][c:35]([F:34])[cH:40][cH:39]1)=[O:43])=[O:46]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-72282b4fcc894e058cec61dc3fbccfca
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…