Dimethylformamide → 2-(4-(1,3-Dioxan-2-yl)-3,5-dimethylphenyl)-5-(1-phenyl-cyclopropyl)thiazolo[5,4-b]pyridine

HRID 961854Notes

Reaction equation

HRID 961854 reaction equation
[Br:19][c:20]1[cH:21][c:22]([CH3:33])[c:23]([CH:27]2[O:28][CH2:29][CH2:30][CH2:31][O:32]2)[c:24]([CH3:26])[cH:25]1.[C:34](=[O:35])([O-:36])[O-:37].[Cs+:38].[Cs+:39].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44].[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][cH:17][n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([c:10]3[cH:11][cH:12][c:13]4[c:14]([n:15]3)[s:16][c:17](-[c:20]3[cH:21][c:22]([CH3:33])[c:23]([CH:27]5[O:28][CH2:29][CH2:30][CH2:31][O:32]5)[c:24]([CH3:26])[cH:25]3)[n:18]4)[CH2:8][CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 591748745-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridineHCID 591748982-(4-Bromo-2,6-dimethylphenyl)-1,3-dioxane

Product 1

HCID 671115052-(4-(1,3-Dioxan-2-yl)-3,5-dimethylphenyl)-5-(1-phenyl-cyclopropyl)thiazolo[5,4-b]pyridine

Sources & evidence

ORD record
ord-d363a9c42abb46a682e0cbd7130dd65e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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