Cyclopropanecarbonyl chloride → Cyclopropylmethyl[3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine
Reaction equation
[CH:39]1([C:42]([Cl:43])=[O:44])[CH2:40][CH2:41]1.[F:1][c:2]1[cH:3][c:4]([CH2:5][NH:6][c:7]2[c:8]([CH:15]3[CH2:16][c:17]4[cH:18][cH:19][c:20]([O:25][CH3:26])[cH:21][c:22]4[CH2:23][CH2:24]3)[cH:9][cH:10][c:11]([O:13][CH3:14])[cH:12]2)[cH:27][cH:28][c:29]1[O:30][CH2:31][CH2:32][N:33]1[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1>>[F:1][c:2]1[cH:3][c:4]([CH2:5][N:6]([c:7]2[c:8]([CH:15]3[CH2:16][c:17]4[cH:18][cH:19][c:20]([O:25][CH3:26])[cH:21][c:22]4[CH2:23][CH2:24]3)[cH:9][cH:10][c:11]([O:13][CH3:14])[cH:12]2)[CH2:42][CH:39]2[CH2:40][CH2:41]2)[cH:27][cH:28][c:29]1[O:30][CH2:31][CH2:32][N:33]1[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-00f3e7c2219347e4b80544f0fa830a67
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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